PAPiSOL is a comprehensive treatment platform for Pulmonary Hypertension (PH) which is associated  with a number of conditions (1) in companion animal medicine.  It can be used in both acute and chronic cases and belongs to a class of drugs called type 5 phosphodiesterase inhibitors (PDE5) which function as pulmonary vascular dilators.

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PAPiSOL's unique chemistry allows it to only dilate the blood vessels in the lung which gives it the most potential for lowering PH while exhibiting no untoward systemic side effects.


PAPiSOL controls pulmonary hypertension as follows:

  • Pulmonary Hypertension is caused by the rise in blood pressure across the lungs (2).

  • PAPiSOL is a selective pulmonary vasodilator.  By specifically dilating the blood vessels in the lungs, it moderates the blood pressure to a manageable level.

  • PAPiSOL is lung specific and does not affect the blood pressure elsewhere in the body (systemic).

How It Works

How It's Used

Episodes of pulmonary hypertension can be classified in two ways, acute and chronic.  PAPiSOL will be available in an oral form to address both acute and chronic conditions.

  • Acute cases occur when the animal is in severe cardio respiratory distress and emergency treatment at an immediate care facility is warranted.  PAPiSOL would be given to immediately moderate the pulmonary arterial pressure.

  • Chronic cases are generally diagnosed via a thorough physical exam by a veterinarian and a long term treatment regimen to control the PH is prescribed. Here the veterinarian would prescribe  PAPiSOL for daily administration by the owner at home for the remainder of the animal's life.

How Do I Buy PAPiSOL?

PAPiSOL is available by prescription from national compounding pharmacies.

1) Canine pulmonary hypertension, Part 2: Diagnosis and treatmentSep 01, 2011By Justin G. Williams, DVM, DACVIM (cardiology), Rebecca Quinn, DVM, DACVIM VETERINARY MEDICINE1234567

2) The Management of Acute Pulmonary Arterial Hypertension - Hui-li ...

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